Mesulid Information:

Life is toobusy, and if we encounter some body pain it reduces our efficiency. Inthis modern age, the hustle and bustle of life does not permit us totake a break. We have to stay fit and strong 24/7. Body pain can reduceour efficiency significantly hence we need some medicine to suppressthe pain. We just need enough to make it through the day, without anyhindrances in work. Mesulid is one such drug. Its fast action has madeit popular over the decades. It is used for the treatment of arthritis,body pain, dental pain, inflammation and dysmenorrhea.

Mesulid has an active ingredient called nimesulide, whichwas developed by Helsinn Healthcare SA, Switzerland. It is one of theoldest among the non-steroidal anti-inflammatory class of drugs and waslaunched in 1985 in Italy. It has become very popular among the NSAIDs,and is available in more than 50 countries across the globe. It has theproperties of a pain killer, anti-pyretic agent (an agent which reducesbody temperature in fever) and an anti-inflammatory agent (an agentwhich reduces swelling).

In the human body there exists an enzyme called Cyclo-oxygenase, whichis accountable for the production of a substance called prostaglandin.Prostaglandin is a fatty acid that stimulates pain in nerve cells,during inflammation, due to a disease or injury. Non-steroidalanti-inflammatory Drugs (NSAIDs) work by inhibiting Cyclo-oxygenase.There are two isoforms of Cyclo-oxygenase, namely Cyclo-oxygenase-1 andCyclo-oxygenase-2. The former is essential for the smooth running andmaintenance of the kidney, cardiovascular, and intestinal functions,whereas the latter is responsible for stimulation of pain in nervecells. Clinical data obtained by different studies indicate thatMesulid effects only Cyclo-oxygenase-2 also called COX-II. Hence it isa COX-II selective NSAID.

As Mesulid does not affect COX-I, it has limited adverse effects onkidney, heart and vascular functions. It also prevents tissue damagethat occurs during inflammation, and thus cures inflammation faster.Mesulid has a superior design, therefore it is more effective and hasless side effects than other NSAIDs. Mesulid is aimed for people ofages 12 and above. It is inadvisable to use it with children under 12years of age. The effective dosage ranges from 100mg to 200mg a day –however, the minimum dosage should be applied.

Mesulid has shown to be hepatotoxic i.e. it damages liver. In some rarestudies, adverse effects of this medicine have been noticed. Mesulidhas rather tolerable common side effects. Usually, patients suffer frommild complaints such as nausea, diarrhea, heartburn or abdominalcramps. But they are only mild and more than often no treatment isrequired.

This article is for informational purposes only. For further instructions on Mesulid consult with your doctor.s